O-3-tert-Butylphenyl (6-methoxy-2-pyridyl)(methyl)thiocarbamate

Name	Pyributicarb
Synonyms	tsh-888 henyl)ester PYRIBUTYCARB Pyributicarb PYRIBUTICARB O-3-tert-Butylphenyl (6-methoxy-2-pyridyl)(methyl)thiocarbamate n-(6-methoxy-2-pyridyl)-n-methyl-thiocarbamicacio-3-tert-butylphenyleste carbamothioicacid,(6-methoxy-2-pyridinyl)methyl-,o-(3-(1,1-dimethylethyl)p n-(6-methoxy-2-pyridyl)-n-methylthiocarbamic acid o-3-tert-butylphenyl ester
CAS	88678-67-5

Molecular Formula	C18H22N2O2S
Molar Mass	330.44
Density	1.1453 (rough estimate)
Melting Point	85～88℃
Boling Point	427.8±55.0 °C(Predicted)
Appearance	neat
pKa	1.22±0.10(Predicted)
Storage Condition	0-6°C
Refractive Index	1.6000 (estimate)
In vitro study	Pyributicarb, a carbamate-type herbicide, is a potent activator of both CYP3A4 gene and human pregnane X receptor (hPXR). Pyributicarb is found to increase the CYP3A4 reporter activity at 0.1 to 1 μM more strongly than typical CYP3A4 inducer rifampicin. Expression of hPXR-siRNA clearly diminishes the Pyributicarb-stimulated CYP3A4 reporter activity in 3-1-10 cells and decreases the endogenous CYP3A4 mRNA levels in HepG2 cells. Pyributicarb induces luciferase transcription via hPXR at low concentrations in the order of 10 nM. The relative potency of Pyributicarb for hPXR is 8.6-fold that of rifampicin (RIF).
In vivo study	Pyributicarb causes enhancement of CYP3A4 -derived reporter activity in mouse livers introduced with hPXR by adenovirus.

Hazard Symbols	N - Dangerous for the environment
Risk Codes	50/53 - Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
Safety Description	61 - Avoid release to the environment. Refer to special instructions / safety data sheets.
UN IDs	UN 3077 9 / PGIII
WGK Germany	3
RTECS	XK4962000
HS Code	29333990

biological activity	Pyributicarb is a carbamate herbicide, which is an effective activator of CYP3A4 gene and human pregnane X receptor (hPXR).
target	CYP3A4, hPXR
in vitro research	Pyributicarb, a carbamate-type herbicide, is a potent activator of both CYP3A4 gene and human pregnane X receptor (hPXR). Pyributicarb is found to increase the CYP3A4 reporter activity at 0.1 to 1 μM more strongly than typical CYP3A4 inducer rifampicin. Expression of hPXR-siRNA clearly diminishes the Pyributicarb-stimulated CYP3A4 reporter activity in 3-1-10 cells and decreases the endogenous CYP3A4 mRNA levels in HepG2 cells. Pyributicarb induces luciferase transcription via hPXR at low concentrations in the order of 10 nm. The relative potency of Pyributicarb for hPXR is 8.6-fold that of rifampicin (RIF).
in vivo studies	Pyributicarb uses enhancement of CYP3A4 -derived reporter activity in mouse lives introduced with hPXR by adenovirus.

Last Update：2024-04-09 19:05:03

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