O-3-tert-Butylphenyl (6-methoxy-2-pyridyl)(methyl)thiocarbamate
Pyributicarb
CAS: 88678-67-5
Molecular Formula: C18H22N2O2S
O-3-tert-Butylphenyl (6-methoxy-2-pyridyl)(methyl)thiocarbamate - Names and Identifiers
O-3-tert-Butylphenyl (6-methoxy-2-pyridyl)(methyl)thiocarbamate - Physico-chemical Properties
| Molecular Formula | C18H22N2O2S |
| Molar Mass | 330.44 |
| Density | 1.1453 (rough estimate) |
| Melting Point | 85～88℃ |
| Boling Point | 427.8±55.0 °C(Predicted) |
| Appearance | neat |
| pKa | 1.22±0.10(Predicted) |
| Storage Condition | 0-6°C |
| Refractive Index | 1.6000 (estimate) |
| In vitro study | Pyributicarb, a carbamate-type herbicide, is a potent activator of both CYP3A4 gene and human pregnane X receptor (hPXR). Pyributicarb is found to increase the CYP3A4 reporter activity at 0.1 to 1 μM more strongly than typical CYP3A4 inducer rifampicin. Expression of hPXR-siRNA clearly diminishes the Pyributicarb-stimulated CYP3A4 reporter activity in 3-1-10 cells and decreases the endogenous CYP3A4 mRNA levels in HepG2 cells. Pyributicarb induces luciferase transcription via hPXR at low concentrations in the order of 10 nM. The relative potency of Pyributicarb for hPXR is 8.6-fold that of rifampicin (RIF). |
| In vivo study | Pyributicarb causes enhancement of CYP3A4 -derived reporter activity in mouse livers introduced with hPXR by adenovirus. |
O-3-tert-Butylphenyl (6-methoxy-2-pyridyl)(methyl)thiocarbamate - Risk and Safety
| Hazard Symbols | N - Dangerous for the environment |
| Risk Codes | 50/53 - Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. |
| Safety Description | 61 - Avoid release to the environment. Refer to special instructions / safety data sheets. |
| UN IDs | UN 3077 9 / PGIII |
| WGK Germany | 3 |
| RTECS | XK4962000 |
| HS Code | 29333990 |
O-3-tert-Butylphenyl (6-methoxy-2-pyridyl)(methyl)thiocarbamate - Reference Information
| biological activity | Pyributicarb is a carbamate herbicide, which is an effective activator of CYP3A4 gene and human pregnane X receptor (hPXR). |
| target | CYP3A4, hPXR |
| in vitro research | Pyributicarb, a carbamate-type herbicide, is a potent activator of both CYP3A4 gene and human pregnane X receptor (hPXR). Pyributicarb is found to increase the CYP3A4 reporter activity at 0.1 to 1 μM more strongly than typical CYP3A4 inducer rifampicin. Expression of hPXR-siRNA clearly diminishes the Pyributicarb-stimulated CYP3A4 reporter activity in 3-1-10 cells and decreases the endogenous CYP3A4 mRNA levels in HepG2 cells. Pyributicarb induces luciferase transcription via hPXR at low concentrations in the order of 10 nm. The relative potency of Pyributicarb for hPXR is 8.6-fold that of rifampicin (RIF). |
| in vivo studies | Pyributicarb uses enhancement of CYP3A4 -derived reporter activity in mouse lives introduced with hPXR by adenovirus. |
Last Update：2024-04-09 19:05:03
Supplier List
Multiple SpecificationsSpot supply
Product Name: TSH-888 Visit Supplier Webpage Request for quotationCAS: 88678-67-5
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: Pyributicarb Visit Supplier Webpage Request for quotationCAS: 88678-67-5
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Multiple Specifications
Product Name: Pyributicarb Visit Supplier Webpage Request for quotationCAS: 88678-67-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Multiple SpecificationsSpot supply
Product Name: TSH-888 Visit Supplier Webpage Request for quotationCAS: 88678-67-5
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: Pyributicarb Visit Supplier Webpage Request for quotationCAS: 88678-67-5
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Multiple Specifications
Product Name: Pyributicarb Visit Supplier Webpage Request for quotationCAS: 88678-67-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History
O-3-tert-Butylphenyl (6-methoxy-2-pyridyl)(methyl)thiocarbamate
Macroporous weakly acid cation exchange resins
乙二胺四乙酸镁二钠盐水合物
3-甲氧基苯甲腈(欢迎咨询价格)
异紫堇定碱
2-(3,4-DIMETHYLPHENOXY)-3-PHENYL-5-PHENYLMETHYLENE-4H-IMIDAZOL-4-ONE
(RS)-2-乙酰基磺酰基甲基-3-苯丙酸
N-[4-(2-Ethoxyethoxy)benzyl]-3-(2-phenoxyethoxy)aniline
四丙烯酸异戊四酯 (含有稳定剂MEHQ)
Homovanillinic acid
Macroporous weakly acid cation exchange resins
乙二胺四乙酸镁二钠盐水合物
3-甲氧基苯甲腈(欢迎咨询价格)
异紫堇定碱
2-(3,4-DIMETHYLPHENOXY)-3-PHENYL-5-PHENYLMETHYLENE-4H-IMIDAZOL-4-ONE
(RS)-2-乙酰基磺酰基甲基-3-苯丙酸
N-[4-(2-Ethoxyethoxy)benzyl]-3-(2-phenoxyethoxy)aniline
四丙烯酸异戊四酯 (含有稳定剂MEHQ)
Homovanillinic acid